CARDIOVASCULAR DEATH IS THE FIRST CAUSE OF DEATH WORLDWIDE

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%
OF SUDDEN DEATHS HA CARDIAC ORIGIN

OF WHICH --->

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%
CORONARY ARTERY DISEASE ISCHERMIA PEOPLE OVER 40 YEARS OF AGE
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%
ARRHYTHMIC PROBLEMS GENETIC CARDIOMYOPATHY PEOPLE UNDER 35 YEARS AGE

Dizzying numbers...

La morte cardiovascolare rappresenta la prima causa di morte al mondo.

L’85% delle Morti Improvvise ha origine cardiaca ed è una causa importante di morte nell’occidente.

Circa l’80% delle morti cardiache improvvise è causato da malattia coronarica legata a fattori di rischio come età avanzata, sesso maschile, familiarità, alti livelli di colesterolo LDL, ipertensione, fumo e diabete e colpisce in prevalenza soggetti con età superiore e 40 anni

Il 20% restante è dato da problematiche aritmiche originate da cardiomiopatie di origine genetica con o senza anomalie strutturali cardiache, la cui sintomatologia spesso è silente e sfugge ai normali controlli di routine dando origine a eventi improvvisi e mortali.

Tali eventi colpiscono in prevalenza soggetti con età inferiore ai 35 anni.

Suscita clamore quando provoca il decesso inaspettato di giovani atleti apparentemente sani, ma la morte cardiaca improvvisa (MCI) uccide ogni anno

Cardiovascular death is the first cause of death worldwide.

85% of Sudden Deaths has cardiac origin and is a significant cause of death in the West.
Around 80% of cardiac related deaths occur in subjects over 40 years of age and as a consequence of coronary heart disease, due to risk factors such as age, sex (men being more prone), family history, high LDL cholesterol, hypertension, smoking and diabetes.

The remaining 20% is related to arrhythmic problems often caused by genetic cardiomyopathy, with or without cardiac structural anomalies. This largely affects people under 35. Despite routine checks genetic cardiomyopathy related symptoms can go undetected, which may later lead to sudden cardiac death.

It stirs uproar when it causes the unexpected death of apparently healthy young athletes, but the “Sudden Cardiac Death” (SCD) kills every year.

60000 dead people in Italy (half of them without any apparent cardiac disease before death) and 350000 in the United States. It is also responsible for most of 4 million deaths from cardiovascular disease in Europe.
Genetic cardiomyopathies which are risk factors for the “Sudden Death” on the overall population are the following:

  • arrhythmogenic cardiomyopathy 1:2000
  • hypertrophic cardiomyopathy 1:500
  • syndrome QT long 1:2500
  • syndrome QT short (unknown, more rare than the long one)
  • Brugada syndrome 1:3000 – 1:10000
  • Catecholaminergic polymorphic ventricular tachycardia 1:10000

Research

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Genetic Mutations

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